Disease Prediction system is based on predictive modeling predicts the disease of the user on the basis of the symptoms that user provides as an input to the system. The system analyzes the symptoms provided by the user as input and gives the probability of the disease as an output Disease Prediction is done by implementing the Decision tree Classifier. Decision tree Classifier calculates the probability of the disease. With big data growth in biomedical and health care communities, accurate analysis of medical data benefits early disease detection, patient care.